I get this error too. It only happens with IE (not Firefox) and it happens to me when I save data from a pop-up window. I have been working with Seapine Support for a very long time on this problem. It seems that QA Wizard loses communications with IE and you get this error. For me, it complete hangs up IE and I have to End the program (IE).
Support finally was able to reproduce the problem but could not fix it. They blamed it on my IE add ons and I tried to run without them, re-install IE, etc. but the problem kept happening. For me this is an intermittent problem so it has been very aggravating.