The clients I'm interested in testing are coded in VB. The applications use Tuxedo for the middleware.
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This type of environment is supported by LoadRunner. LoadRunner supports the building of virtual users with a Tuxedo interface. LoadRunner also supports the use of graphical virtual users with QTP for exercising the front end in VB. Barring any other solution, the use of Citrix or RDP clients could also be used with LoadRunner.