QArun will work on AS400 and IBM mainframes as long as the access to the AS400 and Mainframe is through an emulator. Some software do not work with all emulators - I cannot remember if this is the case with QARun
I have not failed. I've just found 10,000 ways that won't work" --Thomas Edison
I know QARun supports PC3270, HummingBird, Rumba and several emulators. Chances are, QARun will work in your environment, since very few people work in an environment where their PC is directly connected to a MainFrame any more.