The MS updates for Out of Band patches that have the KB 2416447 -.Net Framework 1.1 SP1, KB 2418241 -.Net Framework 2.0 SP2, and KB 2416473 -.Net Framework 3.5 SP1 appear to break QTP.
We are running WinXP SP 3 with QTP v10 installed

Behavior is that the app opens, will open the script, click Run and nothing ever happens & cannot stop the run either. Have to kill the app.
SAs are looking into this.

Most likely is either the KB 2416447 -.Net Framework 1.1 SP1 or KB 2418241 -.Net Framework 2.0 SP2 as those are the ones common to the machines that are broken.